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A Handbook for DNA-Encoded Chemistry

Theory and Applications for Exploring Chemical Space and Drug Discovery

Wiley, J,
E-Book ( PDF mit Adobe DRM )
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This book comprehensively describes the development and practiceof DNA-encoded library synthesis technology. Together, the chaptersdetail an approach to drug discovery that offers an attractiveaddition to the portfolio of existing hit generation technologiessuch as high-throughput screening, structure-based drug discoveryand fragment-based screening. The book:
* Providesa valuable guide for understanding and applying DNA-encodedcombinatorial chemistry
* Helpschemists generate and screen novel chemical libraries of large sizeand quality
* Bridgesinterdisciplinary areas of DNA-encoded combinatorial chemistry- synthetic and analytical chemistry, molecular biology,informatics, and biochemistry
* Showsmedicinal and pharmaceutical chemists how to efficiently broadenavailable "chemical space" for drug discovery
* Providesexpert and up-to-date summary of reported literature forDNA-encoded and DNA-directed chemistry technology and methods


Titel: A Handbook for DNA-Encoded Chemistry
Autoren/Herausgeber: Robert A. Goodnow
Ausgabe: 1. Auflage

ISBN/EAN: 9781118832691

Seitenzahl: 480
Produktform: E-Book
Sprache: Englisch

ROBERT A. GOODNOW, JR. is the ExecutiveDirector of the Chemistry Innovation Centre, Discovery Sciences atAstraZeneca and the Founder of GoodChem Consulting, LLC. He hasextensive experience in drug discovery and chemistry technologiesincluding carbohydrate, combinatorial, oligonucleotide, andanalytical chemistry. Robert Goodnow has authored or coauthorednearly 100 publications and patents and has spoken extensively onthe topics of drug lead finding and the outsourcing of drugdiscovery chemistry. He has lectured as an adjunct professor ofmedicinal chemistry. - Newsletter
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