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ADMET for Medicinal Chemists

A Practical Guide

Wiley, J,
E-Book ( PDF mit Adobe DRM )
In Ihrem Land nicht verfügbar


This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.


Titel: ADMET for Medicinal Chemists
Autoren/Herausgeber: Katya Tsaioun, Steven A. Kates (Hrsg.)
Ausgabe: 1. Auflage

ISBN/EAN: 9780470915097

Seitenzahl: 512
Produktform: E-Book
Sprache: Englisch

KATYA TSAIOUN, PhD, is Chief Scientific Officer of Cyprotexand, previously, president and founder Apredica, which was acquiredby Cyprotex. Both companies specialize in the rapid preclinical invitro assessment of the ADME-Tox (Absorption, Distribution,Metabolism, Elimination, and Toxicity) properties of small-moleculeand peptide therapeutics.
STEVEN A. KATES, PhD is Vice President of Research andDevelopment at Ischemix. He is a highly experienced chemist withover twenty years in R&D for both life science products andhuman therapeutics, and has advanced several compounds through drugdevelopment from early preclinical to early clinical development.He has more than 100 patents and publications, including onebook.

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