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Alternative Splicing and Disease

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Springer Berlin,
Buch
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Kurzbeschreibung

Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.

Details
Schlagworte

Titel: Alternative Splicing and Disease
Autoren/Herausgeber: Philippe Jeanteur (Hrsg.)
Aus der Reihe: Progress in Molecular and Subcellular Biology
Ausgabe: Softcover reprint of hardcover 1st ed. 2006

ISBN/EAN: 9783642070815

Seitenzahl: 257
Format: 23,5 x 15,5 cm
Produktform: Taschenbuch/Softcover
Gewicht: 421 g
Sprache: Englisch

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