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Basic and Clinical Toxicology of Organophosphorus Compounds

Springer London,
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This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and history. It details the harmful effects of OP exposure on the environment and human health as well clinical management of affected patients.


Titel: Basic and Clinical Toxicology of Organophosphorus Compounds
Autoren/Herausgeber: Mahdi Balali-Mood, Mohammad Abdollahi (Hrsg.)
Ausgabe: Softcover reprint of the original 1st ed. 2014

ISBN/EAN: 9781447170914

Seitenzahl: 257
Format: 23,5 x 15,5 cm
Produktform: Taschenbuch/Softcover
Gewicht: 421 g
Sprache: Englisch

Mahdi Balali-Mood attended
Tehran University, where he was awarded a B.Sc. First-Class Honor in Chemistry
in 1963 and then an M.D. in 1970. After his medical military service and
training in internal medicine and clinical toxicology, he was appointed an
assistant professor in clinical toxicology and became the head of his newly
established Poisoning Treatment Center (PTC) at Mashhad University in 1974. He
was awarded a scholarship from the Ministry of Science of Iran and completed
his Ph.D. in clinical pharmacology and toxicology
at Edinburgh University Medical School (1978–1981). He continued at the school
as a lecturer until 1982, when he decided to return to Mashhad to advance his established
            Dr. Balali-Mood was promoted to associate
professor and then full professor of medicine and clinical toxicology at the
Mashhad University of Medical Sciences (MUMS) in 1984 and 1988, respectively. He has served as a clinical toxicology adviser to the
International Programme on Chemical Safety (IPCS) and the World Health
Organization from 1989 to the present. He has also been a member of the IPCS
Programme Advisory Committee since 2000.
            Dr. Balali-Mood was a founding member
and the first president of the Iranian Society of Toxicology and was twice elected
president of Irantox between 1989 and 2001. He
has been a
member of the Iranian Academy of Medical
Sciences since its establishment in 1990. In
collaboration with a group of internationally recognized medical toxicologists,
he founded the Asia-Pacific Association of Medical Toxicology (in 1989) and
served as the organization’s first vice president and then as its president for
8 years (1994–2001). He was elected as a permanent member of the Academy of
Sciences for the Developing World in 1997. He was also a member of the
Scientific Advisory Board of the Organization for the Prohibition of Chemical
Weapons from 2004 to 2011. Additionally, he is the co-founder of the Medical Toxicology Research Centre,
Faculty of Medicine, Mashhad University of Medical Sciences, where he has
served as director since 1988. He is also Editor-in-Chief
of the Scientific Journal of Birjand
University of Medical Sciences (since 2002) and an associate editor or
editorial board member of numerous national and international medical journals.
Dr. Balali-Mood’s research areas include clinical
toxicology of chemical warfare agents, organophosphorous pesticide poisonings,
heavy metals, drug abuse and overdosage, epidemiology of poisonings, occupational
and environmental toxicology, and natural toxins, including snake and spider venoms.
He is the author or editor of 29 books and book
chapters, 147 articles, and 289 short papers and abstracts. He is also the recipient of several national and international
prizes for teaching, research, and medical care.
Mohammad Abdollahi earned a Pharm.D. in 1988 from the University
of Tehran and later completed a Ph.D. in toxicology and pharmacology in 1994 at
the Tehran University of Medical Sciences. In 2001, Dr. Abdollahi completed his
postdoctoral training in mechanistic toxicology at the University of Toronto’s School
of Pharmacy. While in Toronto, he also contributed to a key meta-analysis study
at the university’s School of Medicine. In 2002 he was given a full professorship
at the Tehran University of Medical Sciences. There he has chaired the
Department of Toxicology and Pharmacology in the
Faculty of Pharmacy since 2005.
Dr. Abdollahi has authored or coauthored more than 600 journal
articles and 48 book chapters and has edited 11 books. He is the
Editor-in-Chief of DARU Journal of
Pharmaceutical Sciences and the Journal
of Medical Hypotheses and Ideas. Additionally, he has served on the
Scientific Advisory Board of the Organization for the Prohibition of Chemical
Weapons (since 2012); as a member of the World Health Organization’s Guidelines
Development Group for the Prevention of Lead Poisoning (since 2011); as a
council member of the Committee on Publication Ethics (2013–2014); as Iran’s
country correspondent to the World Library of Toxicology (since 2008); as a
fellow of the Islamic-World Academy of Sciences (since 2007); on the Board of
Directors of the Iran Chapter of the International Society of Pharmacoeconomics
and Outcomes Research (since 2013), of which is also a founding member; and on
the Board of Directors of the Asian Council of Science Editors (since 2014).
Dr. Abdollahi is the recipient of numerous awards, including
the prestigious award of IAS-COMSTECH in the field of pharmacology and toxicology
(2005). His main research interests are mechanistic and environmental
toxicology, evidence-based medicine, and pharmacology. 

This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

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