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Blood-Brain Barrier in Drug Discovery

Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

Wiley, J,
E-Book ( EPUB mit Adobe DRM )
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Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant - and most challenging - areas of drugdiscovery.
* Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects
* Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies
* Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes
* Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK)
* Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market


Titel: Blood-Brain Barrier in Drug Discovery
Autoren/Herausgeber: Li Di, Edward H. Kerns (Hrsg.)
Ausgabe: 1. Auflage

ISBN/EAN: 9781118788493

Seitenzahl: 600
Produktform: E-Book
Sprache: Englisch

Li Di is an associate research fellow in the Pharmacokinetics, Dynamics, and Drug Metabolism Department at Pfizer Global Research and Development and has extensive experience in the pharmaceutical industry. She has over 100 publications, presented over 70 invited lectures, and teaches an American Chemical Society short course on drug-like properties.
Edward Kerns worked in pharmaceutical research and development for over 30 years, was associate director at Wyeth and Bristol-Myers Squibb, then was at the NIH-National Center for Advancing Translational Sciences. He published over 90 journal papers or book chapters and 3 books, and teaches an American Chemical Society short course on drug-like properties.

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