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Cell Immortalization

Springer Berlin,
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The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim ited normal proliferative potential. Since the long-term proliferative potential of cells concerns regulation of development, regeneration of tissues, and homeostatic control of cell growth, in brief survival of living organisms, and since the regulation of these processes is so different along the evolutionary scale, it is not surpris ing that there does not seem to be any universal trait. The question of whether cells are endowed with finite or infinite prolifera tive phenotypes has to be seen using the perspective of comparative biology.


Titel: Cell Immortalization
Autoren/Herausgeber: Alvaro Macieira-Coelho (Hrsg.)
Aus der Reihe: Progress in Molecular and Subcellular Biology
Ausgabe: Softcover reprint of hardcover 1st ed. 2000

ISBN/EAN: 9783642084911

Seitenzahl: 208
Format: 23,5 x 15,5 cm
Produktform: Taschenbuch/Softcover
Gewicht: 338 g
Sprache: Englisch - Newsletter
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