Drug discrimination: a practical guide to its contributions tothe invention of new chemical entities and evaluations of new orknown pharmacological agents
Drug discrimination can be described as a "drug detection"procedure that uses a pharmacologically active agent as thesubjective stimulus. Although the procedure does require someeffort to implement, it can be an extremely important tool forunderstanding drug action. Whereas medicinal chemists should cometo learn the types of information that drug discrimination studiescan offer, pharmacologists and psychologists might come to realizehow medicinal chemists can apply the types of information that theparadigm routinely provides. Drug Discrimination: Applications toMedicinal Chemistry and Drug Studies provides in-depth analyses ofthe nature and use of drugs as discriminative stimuli and bridgessome of the numerous gaps between medicinal chemistry,pharmacology, and psychology.
Stressing the practical aspects of drug discrimination,including types of procedures, study design, data, andinterpretation, the book details the advantages and limitations ofdrug discrimination studies versus other pharmacologic evaluations.Practical information from leading researchers in the fieldaddresses specific topics and techniques that are of interest indrug discovery, evaluation, and development.
A groundbreaking new guide to the applications of drugdiscrimination studies for medicinal chemistry and neuroscience,Drug Discrimination is essential for any scientist, researcher, orstudent whose interests involve the design, development, and/oraction of drugs acting at the level of the central nervoussystem.