Effective techniques for applying Dynamic CombinatorialChemistry
In a relatively short period, Dynamic Combinatorial Chemistry(DCC) has grown from proof-of-concept experiments in a few isolatedlabs to a broad conceptual framework with applications to anexceptional range of problems in molecular recognition, leadcompound identification, catalyst design, nanotechnology, polymerscience, and others. Bringing together a group of respectedexperts, this overview explains how chemists can apply DCC andfragment-based library methods to lead generation for drugdiscovery and molecular recognition in bioorganic chemistry andmaterials science.
* Basic theory
* Approaches to binding in proteins and nucleic acids
* Molecular recognition
* Catalyst discovery
* Materials discovery
* Analytical chemistry challenges
A comprehensive, single-source reference about DCC methods andapplications including aspects of fragment-based drug discovery,this is a core reference that will spark the development of newsolutions and strategies for chemists building structure librariesand designing compounds and materials.