Progressively builds a deep understanding of macromolecularbehavior
Based on each of the authors' roughly forty years of biophysicsresearch and teaching experience, this text instills readers with adeep understanding of the biophysics of macromolecules. It sets asolid foundation in the basics by beginning with core physicalconcepts such as thermodynamics, quantum chemical models, molecularstructure and interactions, and water and the hydrophobic effect.Next, the book examines statistical mechanics, protein-ligandbinding, and conformational stability. Finally, the authors addresskinetics and equilibria, exploring underlying theory, proteinfolding, and stochastic models.
With its strong emphasis on molecular interactions,Equilibria and Kinetics of Biological Macromolecules offersnew insights and perspectives on proteins and other macromolecules.The text features coverage of:
* Basic theory, applications, and new research findings
* Related topics in thermodynamics, quantum mechanics,statistical mechanics, and molecular simulations
* Principles and applications of molecular simulations in adedicated chapter and interspersed throughout the text
* Macromolecular binding equilibria from the perspective ofstatistical mechanics
* Stochastic processes related to macromolecules
Suggested readings at the end of each chapter include originalresearch papers, reviews and monographs, enabling readers toexplore individual topics in greater depth. At the end of the text,ten appendices offer refreshers on mathematical treatments,including probability, computational methods, Poisson equations,and defining molecular boundaries.
With its classroom-tested pedagogical approach, Equilibriaand Kinetics of Biological Macromolecules is recommended as agraduate-level textbook for biophysics courses and as a referencefor researchers who want to strengthen their understanding ofmacromolecular behavior.