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Basic Science, Epidemiology, Clinical Aspects and Management

Springer Berlin,
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Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.


Titel: Filaggrin
Autoren/Herausgeber: Jacob P. Thyssen, Howard I. Maibach (Hrsg.)
Ausgabe: Softcover reprint of the original 1st ed. 2014

ISBN/EAN: 9783662511176

Seitenzahl: 373
Format: 25,4 x 17,8 cm
Produktform: Taschenbuch/Softcover
Gewicht: 872 g
Sprache: Englisch

Jacob Thyssen has worked in Dermatology for 10 years and holds PhD and DmSci degrees from the University of Copenhagen. He has published 190 articles and 10 book chapters. He has received international awards for his research, including the LEO Pharma Research Foundation for best investigator - Newsletter
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