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Immunochemical Protocols

Humana Press,
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Immunochemical techniques have been in use for many years with early examples of bacterial strain typing dating back to the 1940s. The basis for the science is the exquisite elegance of the mammalian immune system with its ability to recognize foreign proteins and to manufacture antibody m- ecules that strongly bind to the substances that elicited them. Not only are potentially harmful pathogens and toxins recognized by the immune system, but the system can be persuaded to manufacture antibodies to an astonishing array of substances. In the early days of this science, all antibodies for investigative work were produced by immunizing mammals with the substance of interest, followed by regular donor bleeds that yielded antisera. Serum produced in this way yields heterogenic populations of antibody molecules recognizing different epitopes on the target protein, which may be adequate for its intended p- poses, but can also cause problems of crossreactivity. In 1975, Kohler and Milstein reported that spleen cells from immune donor animals could be immortalized, cloned from single cells, and grown in continuous culture. This original work described the method for the production of monoclonal antibodies.


Titel: Immunochemical Protocols
Autoren/Herausgeber: Robert Burns (Hrsg.)
Aus der Reihe: Methods in Molecular Biology
Ausgabe: 3rd ed. 2005

ISBN/EAN: 9781588292742

Seitenzahl: 318
Format: 23,5 x 15,5 cm
Produktform: Hardcover/Gebunden
Gewicht: 642 g
Sprache: Englisch - Newsletter
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