Titel: Induced Pluripotent Stem Cells
Autoren/Herausgeber: Sibel Yildirim
Aus der Reihe: SpringerBriefs in Stem Cells
Format: 23,5 x 15,5 cm
Gewicht: 143 g
Sibel Yildirim is an associate professor at the Faculty of Dentistry, Department of Pediatric Dentistry, University of Selcuk, Konya, Turkey. She has been lecturer and practising dentistry at the university for years. Her colleagues and she have established the first multi-disciplinary, dental/oral research centre in Turkey. She has authored many papers in international journals and has completed several research projects. Along with her pediatric dentistry PhD, she has also her second PhD on histology and embryology. Her research interests include the role of cytokines on deciduous tooth resorption, the viral ethiopathogenesis of pulpal/periapical diseases of deciduous teeth and vital pulpal therapies using recombinant human proteins or gene therapy. Accordingly, she has led some experiments on deciduous tooth pulp tissue and her team obtained important results showing high regulatory capacity of dental pulp cells on the events of deciduous tooth resorption or retention. She had a change to study with the indisputable leaders in the dental engineering field in Japan, Switzerland and the United States. She has become an expert for stem cells from the pulp tissue of deciduous and permanent teeth. She and her colleagues showed dental pulp tissue stem cells have some clear differences than mesenchymal stem cells obtained from umbilical cord stroma. In addition to her dental tissue engineering studies she has pursued re-programming experiments in Geneva. In this part of her studies, she tried to generate the induced pluripotent stem cells (iPSCs) from deciduous vs. permanent dental pulp stem cells, as well as periodontal ligament cells and oral keratinocytes. She could observe that stem cells that have dental origin displayed strong potential for reprogramming. She believes comprehensively that isolating epithelial and mesenchymal stem cells from deciduous teeth and turning them to iPSCs will point toward novel venues for in situ restoration of dental tissue repair.As a pediatric dentist and histologist and embryologist, she does believe she has really powerful tool for understanding cell biology. After long years of experience in academic fields in three different continents she has found herself that she became a student again who is keen to reach beyond the traditional boundaries of biology. After she read Sui Huang’s and Stuart Kaufman’s marvelous manuscripts, she totally convinced that biocomplexity is the only field that helps to achieve her goals; moving one step closer to understanding life.