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Innate Immune Regulation and Cancer Immunotherapy

von
Springer New York,
Buch
234,33 € Lieferbar in 2-3 Tagen
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Kurzbeschreibung

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. This book discusses recent progress in innate immunity and Treg cells, and the regulation of innate immunity through Toll-like receptor (TLR) signalling.

Details
Schlagworte
Hauptbeschreibung

Titel: Innate Immune Regulation and Cancer Immunotherapy
Autoren/Herausgeber: Rong-Fu Wang (Hrsg.)
Ausgabe: 2012

ISBN/EAN: 9781489985903

Seitenzahl: 478
Format: 23,5 x 15,5 cm
Produktform: Taschenbuch/Softcover
Gewicht: 741 g
Sprache: Englisch

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

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