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Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models

Wiley, J,
E-Book ( PDF mit Adobe DRM )
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This book provides a user-friendly, hands-on introduction to theNonlinear Mixed Effects Modeling (NONMEM) system, the most powerfultool for pharmacokinetic / pharmacodynamic analysis.
* Introduces requisite background to using NonlinearMixed Effects Modeling (NONMEM), covering data requirements, modelbuilding and evaluation, and quality control aspects
* Provides examples of nonlinear modeling concepts andestimation basics with discussion on the model buildingprocess and applications of empirical Bayesian estimates in thedrug development environment
* Includes detailed chapters on data set structure,developing control streams for modeling and simulation, modelapplications, interpretation of NONMEM output and results, andquality control
* Has datasets, programming code, and practice exerciseswith solutions, available on a supplementary website


Titel: Introduction to Population Pharmacokinetic / Pharmacodynamic Analysis with Nonlinear Mixed Effects Models
Autoren/Herausgeber: Joel S. Owen, Jill Fiedler-Kelly
Ausgabe: 1. Auflage

ISBN/EAN: 9781118784679

Seitenzahl: 320
Produktform: E-Book
Sprache: Englisch

Joel S. Owen is Professor of Pharmaceutics at Union University, Jackson, Tennessee and President and Principal Scientist of Joel S. Owen, LLC. He has led workshops on NONMEM and PK/PD modeling concepts and applications and served as Director PK/PD at Cognigen Corporation in Buffalo, New York. He has published 16 articles in research publications.
Jill Fiedler-Kelly is Vice President and Chief Scientific Officer of Cognigen Corporation and Adjunct Associate Professor of Pharmaceutical Sciences at the University at Buffalo. She has been teaching workshops and graduate courses on population modeling for over 10 years and has published more than 20 articles and book chapters on pharmacokinetics and pharmacodynamics. - Newsletter
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