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Liposomes

Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers

von
Humana Press,
Buch
176,54 € Lieferbar in 2-3 Tagen

Kurzbeschreibung

One of two volumes dedicated to the latest experimental methods involving lipids, this one focuses on liposome-based nanoscale drug delivery techniques. Chapters include lists of needed materials, reagents, step-by-step protocols and troubleshooting tips.

Details
Schlagworte
Hauptbeschreibung

Titel: Liposomes
Autoren/Herausgeber: Volkmar Weissig (Hrsg.)
Aus der Reihe: Methods in Molecular Biology
Ausgabe: 2010

ISBN/EAN: 9781603273596

Seitenzahl: 564
Format: 25,4 x 17,8 cm
Produktform: Hardcover/Gebunden
Gewicht: 1,400 g
Sprache: Englisch

Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that “the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer” [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.

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