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Mass Spectrometry for Drug Discovery and Drug Development

Wiley, J,
E-Book ( EPUB mit Adobe DRM )
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Facilitates the discovery and development of new, effectivetherapeutics
With coverage of the latest mass spectrometry technology, thisbook explains how mass spectrometry can be used to enhance almostall phases of drug discovery and drug development, including newand emerging applications. The book's fifteen chapters have beenwritten by leading pharmaceutical and analytical scientists. Theircontributions are based on a thorough review of the currentliterature as well as their own experience developing new massspectrometry techniques to improve the ability to discover anddevelop new and effective therapeutics.
Mass Spectrometry for Drug Discovery and Drug Developmentbegins with an overview of the types of mass spectrometers thatfacilitate drug discovery and development. Next it covers:
* HPLC-high-resolution mass spectrometry for quantitativeassays
* Mass spectrometry for siRNA
* Quantitative analysis of peptides
* Mass spectrometry analysis of biological drugs
* Applications that support medicinal chemistryinvestigations
* Mass spectrometry imaging and profiling
Throughout the book, detailed examples underscore the growingrole of mass spectrometry throughout the drug discovery anddevelopment process. In addition, images of mass spectra areprovided to explain how results are interpreted. Extensivereferences at the end of each chapter guide readers to the primaryliterature in the field.
Mass Spectrometry for Drug Discovery and Drug Developmentis recommended for readers in pharmaceutics, including medicinalchemists, analytical chemists, and drug metabolism scientists. Allreaders will discover how mass spectrometry can streamline andadvance new drug discovery and development efforts.


Titel: Mass Spectrometry for Drug Discovery and Drug Development
Autoren/Herausgeber: Walter A. Korfmacher (Hrsg.)
Aus der Reihe: Wiley-Interscience Series on Mass Spectrometry
Ausgabe: 1. Auflage

ISBN/EAN: 9781118516140

Seitenzahl: 476
Produktform: E-Book
Sprache: Englisch

WALTER A. KORFMACHER, PhD, is Director of Bioanalysis atGenzyme, a Sanofi company, and Associate Editor at the Journalof Mass Spectrometry. Previously, he held positions at theFDA's National Center for Toxicological Research, Schering-PloughResearch Institute, Merck Research Laboratories, and MedpaceBioanalytical Laboratories. Dr. Korfmacher is an internationalleader in developing mass spectrometry techniques and strategiesfor new drug discovery and drug metabolism applications. A 2009recipient of the CPSA Distinguished Analytical Scientist Award, hehas published more than 150 articles in the scientific literatureand made more than eighty presentations at various scientificforums.

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