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Mass Spectrometry in Drug Metabolism and Disposition

Basic Principles and Applications

Wiley, J,
E-Book ( EPUB mit Adobe DRM )
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This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.


Titel: Mass Spectrometry in Drug Metabolism and Disposition
Autoren/Herausgeber: Mike S. Lee, Mingshe Zhu (Hrsg.)
Aus der Reihe: Wiley Series on Pharmaceutical Science
Ausgabe: 1. Auflage

ISBN/EAN: 9780470934692

Seitenzahl: 800
Produktform: E-Book
Sprache: Englisch

MIKE S. LEE, PhD, is President of Milestone DevelopmentServices. His recent work has involved the development of automatedorthogonal control systems for electrospray ionization. Formerly,Dr. Lee was director of analytical research and development atBristol-Myers Squibb (BMS) Pharmaceutical Research Institute wherehe led interdisciplinary teams that contributed to the Food andDrug Administration's approval of Buspar® and Serzone®,and the accelerated development and approval of Taxol®. Inaddition, he has authored over forty scientific papers and issuedpatents.
MINGSHE ZHU, PhD, is a drug metabolism researcher atBristol-Myers Squibb, where he leads a team that investigatesbiotransformation in new drug discovery and preclinical drugmetabolism and pharmacokinetics in development. His teams haveprovided key metabolism and disposition information for regulatoryapproval of Abilify® and NDA submission of Dapagliflozin. Dr.Zhu's research interests include LC/MS technology, optimization ofADME properties, metabolic activation, and regulatory drugmetabolism. He has been frequently invited to speak and teach shortcourses at conferences/workshops and has coauthored over sixtyresearch articles and one book.

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