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Molecular Biophysics for the Life Sciences

Springer New York,
E-Book ( PDF mit Adobe DRM )
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This book covers research themes and strategies in molecular biophysics. It explains the goals of biophysical research as well as details investigative tools, the relevance of biological research to other fields, and future opportunities in the field.


Titel: Molecular Biophysics for the Life Sciences
Autoren/Herausgeber: Norma M. Allewell, Linda O. Narhi, Ivan Rayment (Hrsg.)
Aus der Reihe: Biophysics for the Life Sciences
Ausgabe: 2013

ISBN/EAN: 9781461485483

Seitenzahl: 397
Produktform: E-Book
Sprache: Englisch

Dr. Norma M. Allewell is Professor of Cell Biology and Molecular Genetics and Affiliate Professor of Chemistry and Biochemistry at the University of Maryland, where she served as Dean of the College of Chemical and Life Sciences for a decade. Her research focuses on protein structure, function and dynamics, and metabolic regulatory mechanisms and diseases.Dr. Linda Narhi is a Scientific Executive Director in the Product Attribute Science Group at Amgen, where her responsibilities include solution stability assessment of all protein-based therapeutic candidates, and developing and implementing predictive assays for protein stability to process, storage, and delivery conditions. Dr. Ivan Rayment is Professor of Biochemistry at the University of Wisconsin-Madison, where he holds the Michael G. Rossmann Professorship in Biochemistry. He has a wide range of interests in structural biology and has made seminal contributions to our understanding of the structural basis of motility, enzyme evolution, cobalamin biosynthesis, and transposition.

This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution.   It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how the structure, dynamics, and physical properties of biological macromolecules enable them to perform their biological functions.  Reviews of research on three disparate biomolecular machines—DNA helicases, ATP synthases, and myosin--illustrate how the combination of theory and experiment leads to new insights and new questions. 

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