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Physics at the Biomolecular Interface

Fundamentals for Molecular Targeted Therapy

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This book
focuses primarily on the role of interfacial forces in understanding biological
phenomena at the molecular scale. By providing a suitable statistical
mechanical apparatus to handle the biomolecular interface, the book becomes
uniquely positioned to address core problems in molecular biophysics. It
highlights the importance of interfacial tension in delineating a solution to
the protein folding problem, in unravelling the physico-chemical basis of
enzyme catalysis and protein associations, and in rationally designing
molecular targeted therapies. Thus grounded in fundamental science, the book
develops a powerful technological platform for drug discovery, while it is set
to inspire scientists at any level in their careers determined to address the
major challenges in molecular biophysics.
acknowledgment of how exquisitely the structure and dynamics of proteins and their
aqueous environment are related attests to the overdue recognition that
biomolecular phenomena cannot be effectively understood without dealing with
interfacial behaviour. There is an urge to grasp how biologically relevant
behaviour is shaped by the structuring of biomolecular interfaces and how
interfacial tension affects the molecular events that take place in the cell.
This book squarely addresses these needs from a physicist perspective.
book may serve as a monograph for practitioners and, alternatively, as an
advanced textbook. Fruitful reading requires a background in physical chemistry
and some basics in biophysics. The selected problems at the end of the chapters
and the progression in conceptual difficulty make it a suitable textbook for a
graduate level course or an elective course for seniors majoring in chemistry,
physics, biomedical engineering or related disciplines.


Titel: Physics at the Biomolecular Interface
Autoren/Herausgeber: Ariel Fernández
Aus der Reihe: Soft and Biological Matter
Ausgabe: 1st ed. 2016

ISBN/EAN: 9783319308517

Seitenzahl: 483
Format: 23,5 x 15,5 cm
Produktform: Hardcover/Gebunden
Gewicht: 913 g
Sprache: Englisch

Ariel Fernández (born Ariel Fernández Stigliano) is an
Argentine-American physical chemist and mathematician. He obtained his Ph. D. degree
in Chemical Physics from Yale University in record time. He held the Karl F.
Hasselmann Endowed Chair Professorship in Engineering at Rice University and
was a Professor of Bioengineering until his retirement in 2012. To date, he has
published over 350 scientific papers in professional journals including
Physical Review Letters, PNAS, Nature, Genome Research and Genome Biology.
Ariel Fernandez has also published two books: “Transformative Concepts for Drug
Design” (2010) and “Biomolecular Interfaces” (2015), both with Springer, and
holds two patents (US. 8,466,154 and 9,051,387) on biotechnological innovations.
He is currently involved in research and entrepreneurial activities at various
consultancy firms. - Newsletter
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