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Prions and Diseases

Springer New York,
Buch
255,73 € Lieferbar in 5-7 Tagen

Kurzbeschreibung

More than 60 leading researchers and clinicians worldwide cover the latest developments in our understanding of these unique infectious pathogens and their associated diseases, only now divulging their chemical secrets despite being recognized for centuries.

Details
Schlagworte
Hauptbeschreibung

Titel: Prions and Diseases
Autoren/Herausgeber: Wen-Quan Zou, Pierluigi Gambetti (Hrsg.)
Ausgabe: 2013

ISBN/EAN: 9781461453437

Seitenzahl: 670
Format: 23,5 x 15,5 cm
Produktform: Hardcover/Gebunden
Gewicht: 0 g
Sprache: Englisch

Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases.

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