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Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of BCR Signals from the Cell Membrane to the Nucleus

Springer Berlin,
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Kurzbeschreibung

Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Details
Schlagworte

Titel: Signal Transduction and the Coordination of B Lymphocyte Development and Function I
Autoren/Herausgeber: Louis B. Justement, Katherine A. Siminovitch (Hrsg.)
Aus der Reihe: Current Topics in Microbiology and Immunology
Ausgabe: 2000

ISBN/EAN: 9783540660026

Seitenzahl: 267
Format: 23,5 x 15,5 cm
Produktform: Hardcover/Gebunden
Gewicht: 1,290 g
Sprache: Englisch

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