An important role of diagnostic medicine research is to estimateand compare the accuracies of diagnostic tests. This book providesa comprehensive account of statistical methods for design andanalysis of diagnostic studies, including sample size calculations,estimation of the accuracy of a diagnostic test, comparison ofaccuracies of competing diagnostic tests, and regression analysisof diagnostic accuracy data. Discussing recently developed methodsfor correction of verification bias and imperfect reference bias,methods for analysis of clustered diagnostic accuracy data, andmeta-analysis methods, Statistical Methods in Diagnostic Medicineexplains:
* Common measures of diagnostic accuracy and designs for diagnosticaccuracy studies
* Methods of estimation and hypothesis testing of the accuracy ofdiagnostic tests
* Advanced analytic techniques-including methods for comparingcorrelated ROC curves in multi-reader studies, correctingverification bias, and correcting when an imperfect gold standardis used
Thoroughly detailed with numerous applications and end-of-chapterproblems as well as a related FTP site providing FORTRAN programlistings, data sets, and instructional hints, Statistical Methodsin Diagnostic Medicine is a valuable addition to the literature ofthe field, serving as a much-needed guide for both clinicians andadvanced students.