Erweiterte
Suche ›

The Future of Predictive Safety Evaluation

In Two Volumes Volume 1

von
Buch
85,55 € Derzeit nicht lieferbar
Dieses Produkt ist auch verfügbar als:

Kurzbeschreibung

A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.

Details
Schlagworte

Titel: The Future of Predictive Safety Evaluation
Autoren/Herausgeber: D.V. Parke, J. Marks, A.N. Worden (Hrsg.)
Ausgabe: 1986

ISBN/EAN: 9780852008737

Seitenzahl: 224
Format: 0 x 0 cm
Produktform: Hardcover/Gebunden
Gewicht: 530 g
Sprache: Englisch

buchhandel.de - Newsletter
Möchten Sie sich für den Newsletter anmelden?


Bitte geben Sie eine gültige E-Mail-Adresse ein.
Lieber nicht