Renal transplantation is now accepted as the treatment of choice for patients with end-stage renal failure. During the last decade both patients and graft survival rates have increased significantly and when assessed at one year are now greater than 90% and 80% respectively. These marked improvements have occurred at a time when increasing numbers of patients in the older age groups and with more complex forms of renal disease are being accepted for transplantation. The reasons for the improved clinical results are not fully understood but are probably linked with changes in blood transfusion policy, tissue typing policy and drug therapy. These topics, together with immunological monitoring and details of how to treat the highly sensitized patient, are fully covered in this volume. All the chapters have been written by recognized experts in their field. Not only are the recent advances well documented but the likely future developments in management are identified and discussed. As renal transplantation is now the single most common of treatment for renal failure, the information presented in this form volume should prove of value to all with an interest in current clinical practice.